CHLVH Publications


Mechanical cardiopulmonary interactions during exercise in health and disease.

Global REACH 2018: The Effect of an Expiratory Resistance Mask with Dead Space on Sleep and Acute Mountain Sickness During Acute Exposure to Hypobaric Hypoxia.

Modulation of vestibular-evoked responses prior to simple and complex arm movements.

Cerebrovascular reactivity to carbon dioxide is not influenced by variability in the ventilatory sensitivity to carbon dioxide.

HIITing the brain with exercise; mechanisms, consequences and practical recommendations.

Cardiorespiratory fitness and accelerometer-determined physical activity following one year of free-living high-intensity interval training and moderate-intensity continuous training: a randomized trial.

Validation of a Non-invasive Assessment of Pulmonary Gas Exchange During Exercise in Hypoxia.

The influence of age and sex on cerebrovascular reactivity and ventilatory response to hypercapnia in children and adults.

Global REACH: Andean highlanders, chronic mountain sickness and the integrative regulation of resting blood pressure.

Motor unit contributions to activation reduction and torque steadiness following active lengthening: A study of residual torque enhancement.

Effects of circulating extracellular microvesicles from spinal cord-injured adults on endothelial cell function.

Reply to Jensen and Wang: Chimpanzees under pressure-Selection of a left ventricular structural and functional phenotype.

The 2018 Global Research Expedition on Altitude Related Chronic Health (Global REACH) to Cerro de Pasco, Peru: an Experimental Overview.

The Sexes Do Not Differ for Neural Responses to Submaximal Elbow Extensor Fatigue.

Cardiac structure and function in youth with type 2 diabetes in the iCARE cohort study: Cross-sectional associations with prenatal exposure to diabetes and metabolomic profiles.

Global Reach 2018: Heightened α-Adrenergic Signaling Impairs Endothelial Function During Chronic Exposure to Hypobaric Hypoxia.

UBC-Nepal expedition: dynamic cerebral autoregulation is attenuated in lowlanders upon ascent to 5050 m.

A low-carbohydrate protein-rich bedtime snack to control fasting and nocturnal glucose in type 2 diabetes: A randomized trial.

Evidence for a physiological role of pulmonary arterial baroreceptors in sympathetic neural activation in healthy humans.

Potential therapeutic effects of exogenous ketone supplementation for type 2 diabetes: a review.

Rates of compliance and adherence to high-intensity interval training in insufficiently active adults: a systematic review and meta-analysis protocol.

Supplements and Nutritional Interventions to Augment High-Intensity Interval Training Physiological and Performance Adaptations-A Narrative Review.

The effect of blood flow occlusion on corticospinal excitability during sustained low-intensity isometric elbow flexion.

Development and Evaluation of the High-Intensity Interval Training Self-Efficacy Questionnaire.

Forty high-intensity interval training sessions blunt exercise-induced changes in the nuclear protein content of PGC-1α and p53 in human skeletal muscle.

Effects of Exercise Therapy Dosing Schedule on Impaired Cardiorespiratory Fitness in Patients With Primary Breast Cancer: A Randomized Controlled Trial.

The Inhibitory Tendon-Evoked Reflex Is Increased in the Torque-Enhanced State Following Active Lengthening Compared to a Purely Isometric Contraction.

Long-term Exercise Confers Equivalent Neuroprotection in Females Despite Lower Cardiorespiratory Fitness.

Muscle Sympathetic Reactivity to Apneic and Exercise Stress in High-Altitude Sherpa.

Evidence for temperature-mediated regional increases in cerebral blood flow during exercise.

Differential Modulation of Motor Unit Properties from the Separate Components of the Triceps Surae in Humans.

Global REACH: Assessment of Brady-Arrhythmias in Andeans and Lowlanders During Apnea at 4330 m.

Fontan-Associated Liver Disease: Spectrum of Disease in Children and Adolescents.

Cerebral metabolism, oxidation, and inflammation in severe passive hyperthermia with and without respiratory alkalosis.


The Inhibitory Tendon-Evoked Reflex Is Increased in the Torque-Enhanced State Following Active Lengthening Compared to a Purely Isometric Contraction.

Pharmacist-led therapeutic carbohydrate restriction as a treatment strategy for type 2 diabetes: the Pharm-TCR randomized controlled trial protocol.

Cardiac Structure and Function in Youth with Type 2 Diabetes in the iCARE cohort study: cross sectional associations with prenatal exposure to diabetes and metabolomic profiles.

Acute intermittent hypercapnic hypoxia and sympathetic neurovascular transduction in men.

Pathophysiological and clinical considerations in the perioperative care of patients with a previous ischaemic stroke: a multidisciplinary review.

Brain Hypoxia Secondary to Diffusion Limitation in Hypoxic Ischemic Brain Injury Postcardiac Arrest.

Objectively Measured Aerobic Fitness is Not Related to Vascular Health Outcomes and Cardiovascular Disease Risk In 9-10 Year Old Children.

The effects of forearm position and contraction intensity on cortical and spinal excitability during a submaximal force steadiness task of the elbow flexors.

A winning combination: Collaborating with stakeholders throughout the process of planning and implementing a type 2 diabetes prevention programme in the community.

Cardiorespiratory fitness and muscular endurance responses immediately and two-months after a whole-body Tabata or vigorous-intensity continuous training intervention.

Physiological basis of brief vigorous exercise to improve health.

The impact of hypoxaemia on vascular function in lowlanders and high altitude indigenous populations.

Global REACH 2018: The influence of acute and chronic hypoxia on cerebral haemodynamics and related functional outcomes during cold and heat stress.

Sustained Maximal Voluntary Contractions Elicit Different Neurophysiological Responses in Upper- and Lower-Limb Muscles in Men.

Inhibitory tendon evoked reflex is attenuated in the torque depressed isometric steady-state following active shortening.

Dissociating the effects of oxygen pressure and content on the control of breathing and acute hypoxic response.

A ketone monoester drink reduces the glycemic response to an oral glucose challenge in individuals with obesity: a randomized trial.

Influence of methazolamide on the human control of breathing: A comparison to acetazolamide.

Measuring blood flow through intrapulmonary and intracardiac shunts: a technical labyrinth.

Selection of endurance capabilities and the trade-off between pressure and volume in the evolution of the human heart.

Examination of a New Delivery Approach for Oral Cannabidiol in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Pharmacokinetics Study.

Left ventricular mechanics in late second trimester of healthy pregnancy.

Effects of Mobile Health Prompts on Self-Monitoring and Exercise Behaviors Following a Diabetes Prevention Program: Secondary Analysis From a Randomized Controlled Trial.

Could Adjunctive Pharmacology Mitigate Cardiovascular Consequences of Obstructive Sleep Apnea?

Global Reach 2018: reduced flow-mediated dilation stimulated by sustained increases in shear stress in high-altitude excessive erythrocytosis.

UBC-Nepal Expedition: Haemoconcentration underlies the reductions in cerebral blood flow observed during acclimatization to high altitude.

Empirical targets for acute hemodynamic management of individuals with spinal cord injury.

The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives.

The Impact of Different Exercise Intensities on Vasodilation and Shear Rate Patterns in Children.

Objectively Measured Aerobic Fitness is Not Related to Vascular Health Outcomes and Cardiovascular Disease Risk In 9-10 Year Old Children.

The Effects of a Patient and Provider Co-Developed, Behavioral Physical Activity Intervention on Physical Activity, Psychosocial Predictors, and Fitness in Individuals with Spinal Cord Injury: A Randomized Controlled Trial.

High-Altitude Acclimatization Improves Recovery from Muscle Fatigue.

Cerebrovascular function is preserved during mild hyperthermia in cervical spinal cord injury.

Regulation of the Cerebral Circulation by Arterial Carbon Dioxide.

Intracranial pressure and compliance in hypoxic ischemic brain injury patients after cardiac arrest.

Left Ventricular Twist Is Augmented in Hypoxia by β1-Adrenergic-Dependent and β1-Adrenergic-Independent Factors, Without Evidence of Endocardial Dysfunction.

UBC-Nepal expedition: phenotypical evidence for evolutionary adaptation in the control of cerebral blood flow and oxygen delivery at high altitude.

Global REACH 2018: High Blood Viscosity and Hemoglobin Concentration Contribute to Reduced Flow-Mediated Dilation in High-Altitude Excessive Erythrocytosis

Respiratory muscle training in athletes with cervical spinal cord injury: effects on cardiopulmonary function and exercise capacity.

Baroreflex control of sympathetic vasomotor activity and resting arterial pressure at high altitude: insight from Lowlanders and Sherpa.

The Burden of Brain Hypoxia and Optimal Mean Arterial Pressure in Patients With Hypoxic Ischemic Brain Injury After Cardiac Arrest.

Electrocardiographic changes following six months of long-distance triathlon training in previously recreationally active individuals.

Minimal effect of walking before dinner on glycemic responses in type 2 diabetes: outcomes from the multi-site E-PAraDiGM study.

Upward resetting of the vascular sympathetic baroreflex in middle-aged male runners.

Restricting carbohydrates at breakfast is sufficient to reduce 24-hour exposure to postprandial hyperglycemia and improve glycemic variability.

Oral Ketone Supplementation Acutely Increases Markers of NLRP3 Inflammasome Activation in Human Monocytes.

Attention Is Required to Coordinate Reaching and Postural Stability during Upper Limb Movements Generated While Standing.

Challenges and opportunities in exosome research-Perspectives from biology, engineering, and cancer therapy.

The Time Course of Motoneuronal Excitability during the Preparation of Complex Movements.

Cardiac structure and function characterized across age groups and between sexes in healthy wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries.

Reply to: Optic nerve sheath diameter measurement in hypoxic ischaemic brain injury after cardiac arrest.

A preliminary trial examining a ‘real world’ approach for increasing physical activity among breast cancer survivors: findings from project MOVE.

Brief Exercise Counseling and High-Intensity Interval Training on Physical Activity Adherence and Cardiometabolic Health in Individuals at Risk of Type 2 Diabetes: Protocol for a Randomized Controlled Trial.

Prolonged low-frequency force depression is underestimated when assessed with doublets compared with tetani in the dorsiflexors.

Appropriate scaling approach for evaluating peak VO2 development in Southern Chinese 8 to 16 years old.

Sprint exercise snacks: a novel approach to increase aerobic fitness.

Intracranial Vascular Responses to High-Intensity Interval Exercise and Moderate-Intensity Steady-State Exercise in Children.

Short-Term Low-Carbohydrate High-Fat Diet in Healthy Young Males Renders the Endothelium Susceptible to Hyperglycemia-Induced Damage, An Exploratory Analysis.

Short-term exercise training reduces glycaemic variability and lowers circulating endothelial microparticles in overweight and obese women at elevated risk of type 2 diabetes.

Morning exercise mitigates the impact of prolonged sitting on cerebral blood flow in older adults.

The Effect of an Expiratory Resistance Mask with Dead Space on Sleep, Acute Mountain Sickness, Cognition, and Ventilatory Acclimatization in Normobaric Hypoxia.

A Multi-Center Comparison of O2peak Trainability Between Interval Training and Moderate Intensity Continuous Training.

Mapping behavior change techniques to characterize a social cognitive theory informed physical activity intervention for adults at risk of type 2 diabetes mellitus.

The association between polypharmacy and late life deficits in cognitive, physical and emotional capability: a cohort study.

Exploring the effectiveness of a school-based physical activity policy in British Columbia, Canada: a mixed-methods observational study.

Cerebrovascular function in patients with chronic obstructive pulmonary disease: the impact of exercise training.

Static monocular visual cues can decrease the vestibular-evoked balance response at low frequencies.

UBC-Nepal Expedition: Cerebrovascular Responses to Exercise in Sherpa Children Residing at High Altitude.

Do stair climbing exercise “snacks” improve cardiorespiratory fitness?

Spinal Cord Disruption Is Associated with a Loss of Cushing-Like Blood Pressure Interactions.

Corticospinal excitability is enhanced while preparing for complex movements.

Ventilatory responses to acute hypoxia and hypercapnia in humans with a patent foramen ovale.

Work of breathing influences muscle sympathetic nerve activity during semi-recumbent cycle exercise.

Central contributions to torque depression: an antagonist perspective.

Supraspinal Fatigue and Neural-evoked Responses in Lowlanders and Sherpa at 5050 m.

The independent effects of hypovolaemia and pulmonary vasoconstriction on ventricular function and exercise capacity during acclimatisation to 3800 m.

Cardiac consequences of spinal cord injury: systematic review and meta-analysis.

Experimental Spinal Cord Injury Causes Left-Ventricular Atrophy and Is Associated with an Upregulation of Proteolytic Pathways.



Acute heat stress reduces biomarkers of endothelial activation but not macro- or microvascular dysfunction in cervical spinal cord injury.

Cerebrovascular Function in the Large Arteries Is Maintained Following Moderate Intensity Exercise.

UBC-Nepal Expedition: An experimental overview of the 2016 University of British Columbia Scientific Expedition to Nepal Himalaya.

Cerebrovascular function in patients with chronic obstructive pulmonary disease: the impact of exercise training.

UBC-Nepal expedition: peripheral fatigue recovers faster in Sherpa than lowlanders at high altitude.

UBC-Nepal expedition: upper and lower limb conduit artery shear stress and flow-mediated dilation on ascent to 5,050 m in lowlanders and Sherpa.

Differential influence of vitamin C on the peripheral and cerebral circulation after diving and exposure to hyperoxia.

Oxygen therapy improves cerebral oxygen delivery and neurovascular function in hypoxaemic chronic obstructive pulmonary disease patients.

Effect of healthy aging on cerebral blood flow, CO2 reactivity, and neurovascular coupling during exercise.

The independent effects of hypovolaemia and pulmonary vasoconstriction on ventricular function and exercise capacity during acclimatisation to 3800 m.

Evaluating the methods used for measuring cerebral blood flow at rest and during exercise in humans.

Is the Cushing mechanism a dynamic blood pressure-stabilizing system? Insights from Granger causality analysis of spontaneous blood pressure and cerebral blood flow.

Beneficial impacts of regular exercise on platelet function in sedentary older adults: evidence from a randomized 6-mo walking trial.

Influence of myocardial oxygen demand on the coronary vascular response to arterial blood gas changes in humans.

Wavelet decomposition analysis is a clinically relevant strategy to evaluate cerebrovascular buffering of blood pressure after spinal cord injury.

Ventilatory and cerebrovascular regulation and integration at high-altitude.

Similarity between carotid and coronary artery responses to sympathetic stimulation and the role of α1-receptors in humans.

UBC-Nepal Expedition: imposed oscillatory shear stress does not further attenuate flow-mediated dilation during acute and sustained hypoxia.

Physiology of static breath holding in elite apneists.

Differential Systolic and Diastolic Regulation of the Cerebral Pressure-Flow Relationship During Squat-Stand Manoeuvres.

Increased ICP and Its Cerebral Haemodynamic Sequelae.

Highs and lows of hyperoxia: physiological, performance, and clinical aspects.

Severity-dependent influence of isocapnic hypoxia on reaction time is independent of neurovascular coupling.

UBC-Nepal expedition: The use of oral antioxidants does not alter cerebrovascular function at sea level or high altitude.

Increasing cerebral blood flow reduces the severity of central sleep apnea at high altitude.

Chemoreflex mediated arrhythmia during apnea at 5,050 m in low- but not high-altitude natives.

Independent and interactive effects of incremental heat strain, orthostatic stress, and mild hypohydration on cerebral perfusion.

Competitive apnea and its effect on the human brain: focus on the redox regulation of blood-brain barrier permeability and neuronal-parenchymal integrity.

Transient Hypertension after Spinal Cord Injury Leads to Cerebrovascular Endothelial Dysfunction and Fibrosis.

Utilizing RE-AIM to examine the translational potential of Project MOVE, a novel intervention for increasing physical activity levels in breast cancer survivors.

Influence of vagal control on sex-related differences in left ventricular mechanics and hemodynamics.

Hemodynamic effects of incremental lung hyperinflation.

Effects of mild whole body hypothermia on self-paced exercise performance.

The haemodynamic response to incremental increases in negative intrathoracic pressure in healthy humans.

Novel Methods for Reporting of Exercise Dose and Adherence: An Exploratory Analysis.

The effect of an aerobic exercise bout 24 h prior to each doxorubicin treatment for breast cancer on markers of cardiotoxicity and treatment symptoms: a RCT.

Are All Steps Created Equal? Revisiting Pedometer Use during Pulmonary Rehabilitation for Individuals Living with Chronic Obstructive Pulmonary Disease.

Residual force enhancement during submaximal and maximal effort contractions of the plantar flexors across knee angle.

The vestibulomyogenic balance response is elevated following high-intensity lengthening contractions of the lower limb.

Vestibular-Evoked Responses Indicate a Functional Role for Intrinsic Foot Muscles During Standing Balance.

Ventilatory responses to acute hypoxia and hypercapnia in humans with a patent foramen ovale.

Work of breathing influences muscle sympathetic nerve activity during semi-recumbent cycle exercise.

Effect of acetazolamide and methazolamide on diaphragm and dorsiflexor fatigue: a randomized controlled trial.

Attenuation of human hypoxic pulmonary vasoconstriction by acetazolamide and methazolamide.

The effects of age and sex on mechanical ventilatory constraint and dyspnea during exercise in healthy humans.

‘I’m on the train and I can’t stop it’: Western Canadians’ reactions to prediabetes and the role of self-compassion.

Short-term exercise training reduces anti-inflammatory action of interleukin-10 in adults with obesity.

High-Intensity Interval or Continuous Moderate Exercise: A 24-Week Pilot Trial.

The influence of high-intensity interval training and moderate-intensity continuous training on sedentary time in overweight and obese adults.

Evaluation of a community-based, family focused healthy weights initiative using the RE-AIM framework.

Evaluation of an mHealth App (DeStressify) on University Students’ Mental Health: Pilot Trial.

Intermittent hypoxia training: Powerful, non-invasive cerebroprotection against ethanol withdrawal excitotoxicity.

High-Intensity Interval Training Improves Markers of Oxidative Metabolism in Skeletal Muscle of Individuals With Obesity and Insulin Resistance.

Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR.

Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle.

The effect of a short-term low-carbohydrate, high-fat diet with or without postmeal walks on glycemic control and inflammation in type 2 diabetes: a randomized trial.

Editorial: Optimizing Exercise for the Prevention and Treatment of Type 2 Diabetes.

The effect of brief intermittent stair climbing on glycemic control in people with type 2 diabetes: a pilot study.

Exercise increases mitochondrial PGC-1 α content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis.

Impact of high-intensity interval training and moderate-intensity continuous training on resting and postexercise cardiac troponin T concentration.

Cardiovascular benefits of combined interval training and post-exercise nutrition in type 2 diabetes.

Carbohydrate restriction with postmeal walking effectively mitigates postprandial hyperglycemia and improves endothelial function in type 2 diabetes.

The association between polypharmacy and late life deficits in cognitive, physical and emotional capability: a cohort study.

Central contributions to torque depression: an antagonist perspective.

Fatigue-related group III/IV muscle afferent feedback facilitates intracortical inhibition during locomotor exercise.

Impact of age on the development of fatigue during large and small muscle mass exercise.

Neuromuscular adaptations to healthy aging.

Reply from Luca Ruggiero, Alexandra F. Yacyshyn, Jane Nettleton and Chris J. McNeil.

The Effects of Sex and Motoneuron Pool on Central Fatigue.

UBC-Nepal expedition: acclimatization to high-altitude increases spinal motoneurone excitability during fatigue in humans.

Low frequency electrical muscle stimulation and endothelial function in advanced heart failure patients.

Carotid artery wall mechanics in young males with high cardiorespiratory fitness.

Effect of exercise training on left ventricular mechanics after acute myocardial infarction-an exploratory study.

Reduced left ventricular filling following blood volume extraction does not result in compensatory augmentation of cardiac mechanics.

Right Ventricular Structure and Function in the Veteran Ultramarathon Runner: Is There Evidence for Chronic Maladaptation?

Cardiovascular response to prescribed detraining among recreational athletes.

An exploratory investigation of echocardiographic parameters and the effects of posture on cardiac structure and function in the Livingstone’s fruit bat (Pteropus livingstonii).



Creatine Monohydrate Supplementation Does Not Augment Fitness, Performance, or Body Composition Adaptations in Response to Four Weeks of High-Intensity Interval Training in Young Females